Single-molecule and enriched fractions
From extract to molecule.
Compound isolation, structural characterisation, and analytical method development for clients pursuing single-molecule or enriched-fraction products. Positioned alongside contract research organisations as a complementary upstream partner.
METHODS
LABS
DELIVERABLE
MATRIX
01 · Analytical techniques
The working techniques.
Isolation and characterisation work is run through the partner laboratory matrix — ISO 17025 accredited facilities in the EU and US. Motark, via our manufacturing partners, will coordinate the programme; the analytical work is performed at the partner accredited for the method.
Preparative HPLC
Reversed-phase and normal-phase preparative chromatography for milligram-to-gram isolation of single compounds against an analytical reference.
LC-MS confirmation
Mass-spectral identity confirmation against reference standards or de novo structural attribution at the partner laboratory matrix.
NMR characterisation
¹H, ¹³C, and 2D NMR characterisation through partner academic and contract laboratories for unambiguous structural attribution.
Enriched fractions
Where single-molecule isolation is not the brief, standardised enriched fractions with marker ratios and residual-profile characterisation.
02 · Positioning
Upstream of the CRO.
Three positioning points that determine whether Motark is the right isolation partner for a programme.
01
Upstream of the CRO, not in competition with it
Motark supplies the standardised starting material with chemotype characterised against a reference standard. The Contract Research Organisation (CRO) performs the clinical or preclinical work on that material. The relationship is complementary.
02
Single-molecule and enriched fractions, separately scoped
Single-molecule isolation engagements are scoped against milligram-to-gram deliverables with full structural characterisation. Enriched-fraction engagements are scoped against marker ratios and run on the standard commercial-supply timeline.
03
Method handed over to the client
Where a method is developed for a client programme — HPLC marker, LC-MS confirmation, or stability protocol — the validated method is transferred to the client at programme handover. The client owns the method going forward.
Isolation brief
Start the conversation.
Target compound, expected deliverable scale, and the downstream programme context. Initial scoping call within five working days.