Compound register
Mood · South AfricaStandardisation

Kanna

Sceletium tortuosum

Fermented Sceletium tortuosum from Southern African sourcing partnerships. Alkaloid-standardised extract, mood-regulation applications.

Alkaloid-standardised (HPLC-MS)Fermented extract
HPLC-MSALKALOIDS
METHOD
PROFILEDALKALOID
FINGERPRINT
80MESH
US STD
24 moSHELF
LIFE

Botanical reference

Sceletium tortuosum.

Family
Aizoaceae
Plant part
Whole plant (fermented)
Origin
South Africa

Overview

Kanna (Sceletium tortuosum (L.) N.E.Br.) is a low-growing succulent of the Aizoaceae family, native to the Western and Northern Cape of South Africa. Motark sources Kanna from a Southern African grower network.

The harvested plant material is fermented prior to extraction in a controlled process that increases the mesembrine-type alkaloid fraction and reduces less-desirable components. Extraction is performed in GMP-aligned facilities, with the alkaloid fraction characterised by HPLC-MS against a reference standard. The standardisation tier is set to the formulation brief.

Traditional use

Sceletium tortuosum has a documented history of use among the Khoi-San communities of southern Africa, with European-language records dating to the seventeenth century. Traditional preparation centres on a controlled fermentation of the macerated plant, after which the material is dried and consumed in chewed or infused form.

Motark's compound monograph documents the traditional context as cultural background only. No therapeutic claims are made and no dosage guidance is provided through this site — these are matters for licensed practitioners and the regulatory frameworks of the markets in which finished products are sold.

Modern research

The principal characterised constituents of Sceletium tortuosum are a family of alkaloids of the mesembrine type, including mesembrine, mesembrenone, mesembrenol, and mesembranol. Motark characterises the alkaloid fraction by HPLC-MS against a reference standard, with the tier set to the formulation brief.

Published peer-reviewed work covers phytochemistry, fermentation chemistry, and analytical method development. Citations available on request from the team.

Specifications

Release spec.

Standard commercial specification below. Higher-spec tiers and custom standardisations available against the formulation brief.

Botanical name
Sceletium tortuosum (L.) N.E.Br.
Family
Aizoaceae
Plant part
Whole plant (fermented)
Extraction solvent
Hydroalcoholic
Standardisation marker
Total mesembrine-type alkaloids (HPLC-MS)
Specification
Standardised on total mesembrine-type alkaloids; tier set to formulation brief
Appearance
Brown-green powder
Particle size
80 mesh typical (US standard); alternative grinds on request
Loss on drying
Typical ≤ 7%
Heavy metals
ICP-MS — compliant with USP, EP, and JP limits
Microbial
Compliant with USP, EP, and JP microbial limits for botanical extracts
Pesticide residues
Compliant with USP <565>, EU MRLs

Markers and supply

Active markers and packaging.

Active markers

  • Total mesembrine-type alkaloids

    Standardised; tier to formulation brief

    Method: HPLC-MS

Packaging

Bulk powder
Fibre drums (food-grade liner, vacuum-sealed)
Custom packaging
Available on request for OEM partners

Storage

Store in a cool, dry place away from direct sunlight. Keep container tightly closed and protected from moisture.

Shelf life: Up to 24 months from date of manufacture when stored sealed under specified conditions

Structure · 2DCID 3941622D chemical structure of Total alkaloidsTotal alkaloids

Structure & references

Total alkaloids.

The release marker for Kanna is Total alkaloids, quantified by hplc-ms against a reference standard at a specification of HPLC-MS standardised.

PubChem record

CID 394162

Structural data, IUPAC name, SMILES, and physicochemical properties mirrored from the canonical record at the US National Library of Medicine.

Regulatory status

Status by market.

Status by market for buyer reference. Counterparties are responsible for compliance in the destination market.

Market
Status
Notes
United States
Dietary ingredient
European Union
Novel food (under review)
Novel food authorisation pathway active

Applications

Common uses.

  • Capsule and tablet supplements for mood, focus, and stress
  • Sublingual sprays and tincture formulations
  • Mood-stack and adaptogen blends
  • Functional beverage and confectionery applications (where permitted)
  • Custom-spec extract supply for OEM and contract manufacturers

For procurement and formulation

Sample or quote.

Request a representative sample, or pricing for your annual volume.